Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.51 |
| ▸ | F2 | P00734 | 10/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355874 | 0.81 | CD274 (0.54) | CD274F2HRH3 | |
| SCHEMBL6173777 | 0.79 | F2 (0.67) | CD274F2 | |
| SCHEMBL7446083 | 0.75 | F2 (0.60) | CD274F2HRH3 | |
| SCHEMBL7348647 | 0.74 | F2 (0.53) | CD274F2HRH3 | |
| SCHEMBL7447052 | 0.73 | CD274 (0.55) | CD274F2HRH3 | |
| SCHEMBL6172550 | 0.73 | F2 (0.76) | CD274F2 | |
| SCHEMBL6173290 | 0.73 | ESR1 (0.52) | F2 | |
| SCHEMBL7353107 | 0.73 | HRH3 (0.48) | CD274F2HRH3 | |
| SCHEMBL7452057 | 0.72 | HRH3 (0.54) | CD274F2HRH3 | |
| SCHEMBL6172092 | 0.71 | F2 (0.73) | CD274F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288105-B1 | COMPOUNDS SUCH AS (S)-2-(4-((2-AMINO-3-HYDROXY-1-OXOPROPYL)AMINO)PHENYL)-6-HYDRO XY-3-(3-METHOXY-4-(1-PYRROLIDINYLMETHYL)BENZYL)BENZO(B)THIOPHE NE | ELI LILLY AND COMPANY | 2001-09-11 | — | — | US | disclosed |