Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.59 |
| ▸ | FLT1 | P17948 | 4/20 | 0.58 |
| ▸ | FLT4 | P35916 | 4/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.36 |
| ▸ | NFATC1 | O95644 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976915 | 0.93 | KDR (0.59) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7551299 | 0.89 | KDR (0.44) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7546102 | 0.89 | KDR (0.75) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7550379 | 0.88 | KDR (0.47) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7550486 | 0.87 | KDR (0.44) | KDRFLT1FLT4NFATC1GSK3B | |
| SCHEMBL7557243 | 0.87 | KDR (0.77) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7993928 | 0.86 | KDR (0.78) | KDRFLT1FLT4CYP2A6NFATC1 | |
| SCHEMBL7994055 | 0.84 | KDR (0.56) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7549555 | 0.83 | KDR (0.56) | KDRFLT1FLT4CYP2A6GSK3B | |
| SCHEMBL7550682 | 0.82 | KDR (0.44) | KDRFLT1FLT4NFATC1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265473-B1 | STABILIZER; HEAT AND OXIDATION RESISTANCE; PHOTOSTABILITY | CIBA SPECIALTY CHEMICALS CORP. | 2001-07-24 | — | — | US | disclosed |
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |