Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | FLT1 | P17948 | 4/20 | 0.55 |
| ▸ | FLT4 | P35916 | 4/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.35 |
| ▸ | IL1B | P01584 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550735 | 0.89 | KDR (0.42) | KDRFLT1FLT4IL1BP2RX7 | |
| SCHEMBL7547866 | 0.88 | KDR (0.40) | KDRFLT1FLT4IL1BP2RX7 | |
| SCHEMBL7552023 | 0.87 | KDR (0.40) | KDRFLT1FLT4IL1BP2RX7 | |
| SCHEMBL7551698 | 0.87 | KDR (0.73) | KDRFLT1FLT4CYP2A6IL1B | |
| SCHEMBL7546102 | 0.86 | KDR (0.75) | KDRFLT1FLT4CYP2A6 | |
| SCHEMBL7990322 | 0.86 | KDR (0.73) | KDRFLT1FLT4CYP2A6 | |
| SCHEMBL7553661 | 0.84 | SLC6A4 (0.40) | KDRFLT1FLT4HTR7 | |
| SCHEMBL7557708 | 0.84 | KDR (0.56) | KDRFLT1FLT4CYP2A6HTR7 | |
| SCHEMBL7976012 | 0.84 | KDR (0.59) | KDRFLT1FLT4CYP2A6TDP2 | |
| SCHEMBL7976915 | 0.84 | KDR (0.59) | KDRFLT1FLT4CYP2A6TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265403-B1 | TYROSINE INHIBITORS | MERCK & CO., INC. | 2001-07-24 | — | — | US | disclosed |