Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976105 | 1.00 | CDK5 (0.47) | CDK5CDK5R1GSK3BPLK4DAPK3 | |
| SCHEMBL3000687 | 0.80 | GSK3B (0.50) | CDK5GSK3BPLK4DAPK3DYRK3 | |
| SCHEMBL7982325 | 0.75 | TUBB4A (0.54) | CDK5CDK5R1PARP1TUBB4ATUBB | |
| SCHEMBL1144599 | 0.75 | PLK4 (0.68) | CDK5GSK3BPLK4DAPK3DYRK3 | |
| SCHEMBL13248535 | 0.73 | MAPKAPK2 (0.57) | CDK5CDK5R1MAPK1MAPKAPK2MAPT | |
| SCHEMBL3000848 | 0.68 | MAPKAPK2 (0.73) | CDK5CDK5R1MAPK1MAPKAPK2LMNA | |
| SCHEMBL3000844 | 0.68 | MAPKAPK2 (0.73) | CDK5CDK5R1MAPK1MAPKAPK2LMNA | |
| SCHEMBL13341123 | 0.67 | CDK5 (0.62) | CDK5CDK5R1GSK3BMAPKAPK2TUBB4A | |
| SCHEMBL3426070 | 0.67 | CDK5 (0.62) | CDK5CDK5R1GSK3BMAPKAPK2TUBB4A | |
| SCHEMBL3426073 | 0.67 | CDK5 (0.62) | CDK5CDK5R1GSK3BMAPKAPK2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001064680-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | claimed |
| WO-2001064680-A1 | MYT1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-07 | — | — | WO | disclosed |