Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204342 | 0.84 | KDM4E (0.52) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL427048 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL7974996 | 0.83 | HIF1A (0.58) | SMN1; SMN2TDP1CYP1A2ALDH1A1KMT2A | |
| SCHEMBL427047 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL7976764 | 0.83 | SMN1; SMN2 (0.50) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL12313339 | 0.81 | NTRK1 (0.51) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL24316287 | 0.80 | CYP1A2 (0.52) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL676887 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL12265795 | 0.80 | POLB (0.51) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 | |
| SCHEMBL13211426 | 0.80 | KMT2A (0.51) | SMN1; SMN2TDP1MAPTLIN28AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |