Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 17/20 | 0.71 |
| ▸ | RAB9A | P51151 | 16/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 15/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.56 |
| ▸ | RELA | Q04206 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11947463 | 0.84 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL26525964 | 0.82 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL4037120 | 0.82 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL334041 | 0.81 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL8900290 | 0.81 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL12380049 | 0.80 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL3517537 | 0.80 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL5206454 | 0.79 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL5717831 | 0.77 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL5717616 | 0.77 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |