SCHEMBL7977421

SCHEMBL7977421

COc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)/C=C/c4ccc(C(=O)Nc5ccccn5)nc4)c3Cl)cccc2n1C

nearest known ligand 0.81

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7977422 1.00 BDKRB2 (0.81) BDKRB2
SCHEMBL7981502 0.91 BDKRB2 (0.78) BDKRB2
SCHEMBL7981506 0.91 BDKRB2 (0.78) BDKRB2
SCHEMBL7975717 0.91 BDKRB2 (0.81) BDKRB2
SCHEMBL7975708 0.91 BDKRB2 (0.81) BDKRB2
SCHEMBL7978830 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL7978832 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL7965617 0.90 BDKRB2 (0.79) BDKRB2
SCHEMBL7965614 0.90 BDKRB2 (0.79) BDKRB2
SCHEMBL7975626 0.89 BDKRB2 (0.81) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194396-B1 ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-02-27 US disclosed
US-6083961-A FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 US disclosed
EP-0774462-A1 HETEROCYCLIC COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-21 EP disclosed