SCHEMBL7977569

SCHEMBL7977569

CN(C)c1nc2c(O)cccc2n1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.42
TLR8 Q9NR97 1/20 0.42
CSNK2A2 P19784 1/20 0.39
CSNK2B P67870 1/20 0.39
CSNK2A1 P68400 1/20 0.39
ACHE P22303 1/20 0.38
METAP2 P50579 2/20 0.37
HTR2C P28335 3/20 0.36
HTR2A P28223 2/20 0.36
HTR2B P41595 2/20 0.36
MAPT P10636 4/20 0.36
GAA P10253 2/20 0.36
LMNA P02545 1/20 0.36
ALDH1A1 P00352 3/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
HPGD P15428 1/20 0.36
RECQL P46063 1/20 0.36
RAB9A P51151 2/20 0.35
MMP2 P08253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6654439 0.78 TLR8 (0.46) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL3194071 0.77 CYP1A2 (0.49) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL21555491 0.75 TLR8 (0.59) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL7981680 0.75 TLR8 (0.41) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL7965466 0.74 TLR8 (0.43) KDM4ETLR8ACHEMETAP2HTR2C
SCHEMBL7965248 0.72 TLR8 (0.42) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL7011080 0.72 ACHE (0.42) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL7975692 0.72 TLR8 (0.49) KDM4ETLR8ACHEMETAP2MAPT
SCHEMBL7981849 0.71 TLR7 (0.50) KDM4ETLR8METAP2MAPTGAA
SCHEMBL14685203 0.71 SMN1; SMN2 (0.57) KDM4EMAPTGAALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194396-B1 ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-02-27 US disclosed
US-6083961-A FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 US disclosed
EP-0774462-A1 HETEROCYCLIC COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-21 EP disclosed