Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.84 |
| ▸ | JAK1 | P23458 | 7/20 | 0.80 |
| ▸ | JAK3 | P52333 | 8/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.72 |
| ▸ | IKBKB | O14920 | 1/20 | 0.60 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655773 | 0.91 | JAK2 (0.84) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL3213555 | 0.91 | JAK2 (1.00) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7977780 | 0.90 | JAK2 (0.82) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL16248910 | 0.89 | JAK2 (0.68) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7964178 | 0.89 | JAK2 (0.81) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL13073377 | 0.89 | JAK2 (0.71) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7980632 | 0.89 | JAK1 (1.00) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7964541 | 0.89 | JAK2 (0.79) | JAK2JAK1JAK3PTK2IKBKB | |
| SCHEMBL7985666 | 0.88 | JAK2 (0.66) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL7963267 | 0.88 | JAK2 (0.78) | JAK2JAK1JAK3PTK2IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |