Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.66 |
| ▸ | JAK1 | P23458 | 5/20 | 0.63 |
| ▸ | JAK3 | P52333 | 7/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193345 | 0.91 | JAK2 (0.76) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3215657 | 0.90 | JAK2 (0.63) | JAK2JAK1JAK3PTK2ABL1 | |
| SCHEMBL3192928 | 0.89 | JAK2 (0.62) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL7977771 | 0.88 | JAK2 (0.84) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3205724 | 0.85 | JAK2 (0.57) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3214773 | 0.84 | JAK2 (0.56) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL16248909 | 0.83 | JAK2 (0.64) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3201060 | 0.83 | JAK2 (0.63) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3194461 | 0.83 | JAK1 (0.64) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL3213754 | 0.81 | JAK1 (0.54) | JAK2JAK1JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010188-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES. | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |