Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978005 | 1.00 | NAMPT (0.46) | NAMPTF2ROCK1ROCK2LSS | |
| SCHEMBL11157133 | 0.92 | NAMPT (0.49) | NAMPTROCK1ROCK2SMN1; SMN2PRKACA | |
| SCHEMBL8920080 | 0.81 | NAMPT (0.40) | NAMPTMAPK1ALDH1A1LMNAQPCT | |
| SCHEMBL8918750 | 0.79 | HRH4 (0.41) | NAMPTALDH1A1MAPTQPCT | |
| SCHEMBL11157679 | 0.78 | NAMPT (0.57) | NAMPTALDH1A1GAALMNA | |
| SCHEMBL8200235 | 0.78 | CYP17A1 (0.46) | NAMPTROCK1ROCK2PRKACAGSK3A | |
| SCHEMBL8919055 | 0.78 | HRH4 (0.40) | NAMPTALDH1A1MAPTQPCT | |
| SCHEMBL9298552 | 0.76 | MEN1 (0.46) | NAMPTALDH1A1LMNA | |
| SCHEMBL7900515 | 0.75 | HRH4 (0.54) | NAMPTSMN1; SMN2 | |
| SCHEMBL7898798 | 0.75 | HRH4 (0.54) | NAMPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255323-B1 | Cyanoguanidine compounds | SHIONOGI BIORESEARCH CORP. | 2001-07-03 | — | — | US | disclosed |