Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.41 |
| ▸ | NOS1 | P29475 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGR | P09769 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9838250 | 0.86 | P2RX7 (0.50) | NOS3NOS1ADRB2ADRB1ADRB3 | |
| SCHEMBL11157133 | 0.83 | NAMPT (0.49) | NAMPTALDH1A1HTTCA9PLIN1 | |
| SCHEMBL10453432 | 0.83 | MEN1 (0.44) | MEN1KMT2AFLT1MCL1SLC1A3 | |
| SCHEMBL11157679 | 0.77 | NAMPT (0.57) | MEN1KMT2ANAMPTABCC9KCNJ11 | |
| SCHEMBL9530548 | 0.77 | MEN1 (0.48) | MEN1KMT2ANOS3NOS1JAK2 | |
| SCHEMBL9530547 | 0.77 | MEN1 (0.48) | MEN1KMT2ANOS3NOS1JAK2 | |
| SCHEMBL7978005 | 0.76 | NAMPT (0.46) | NAMPTALDH1A1LMNA | |
| SCHEMBL7978003 | 0.76 | NAMPT (0.46) | NAMPTALDH1A1LMNA | |
| SCHEMBL9297486 | 0.73 | ABCC9 (0.46) | KMT2ANOS3NOS1ABCC9KCNJ11 | |
| SCHEMBL9838248 | 0.70 | NAMPT (0.57) | NAMPTMAOAABCC9KCNJ11MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011837-A | Aryl cyanoguanidines: potassium channel activators and method of making same | E. R. SQUIBB & SONS, INC. (US) | 1991-04-30 | — | — | US | claimed |
| EP-0354553-A2 | Aryl cyanoguanidines: potassium channel activators and method of making same | E.R. SQUIBB & SONS, INC. (US) | 1990-02-14 | — | — | EP | claimed |
| US-5278169-A | Method of treating or prevention of fibrillation of the heart | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5011837-A | Aryl cyanoguanidines: potassium channel activators and method of making same | E. R. SQUIBB & SONS, INC. (US) | 1991-04-30 | — | — | US | disclosed |