Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.74 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | PRKACA | P17612 | 1/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965274 | 0.87 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL7976884 | 0.85 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL1262166 | 0.85 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL14040743 | 0.85 | EGFR (0.76) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL8819515 | 0.85 | EGFR (0.74) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL7978491 | 0.82 | EGFR (1.00) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL8817803 | 0.81 | EGFR (0.74) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL8817814 | 0.81 | EGFR (0.68) | EGFRERBB2MEN1KMT2ATNK2 | |
| SCHEMBL7981320 | 0.79 | EGFR (0.73) | EGFRERBB2KDM4EMAPK1HTT | |
| SCHEMBL11965408 | 0.79 | EGFR (0.78) | EGFRERBB2KDM4EMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313292-B1 | REACTION FROM 5-AMINO-2-FLUOROPYRIDINE; AMINATION, CYCLIZATION, CHLORINATION, SALT FORMATION, DECHLORINATION, DEBLOCKING | WARNER-LAMBERT COMPANY | 2001-11-06 | — | — | US | claimed |
| WO-1997026259-A1 | IMPROVED PROCESS FOR PREPARING 4,6-DISUBSTITUTED PYRIDO[3,4-d]PYRIMIDINES | WARNER-LAMBERT COMPANY (US) | 1997-07-24 | — | — | WO | claimed |
| US-6313292-B1 | REACTION FROM 5-AMINO-2-FLUOROPYRIDINE; AMINATION, CYCLIZATION, CHLORINATION, SALT FORMATION, DECHLORINATION, DEBLOCKING | WARNER-LAMBERT COMPANY | 2001-11-06 | — | — | US | disclosed |