Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 4/20 | 0.57 |
| ▸ | BRAF | P15056 | 4/20 | 0.48 |
| ▸ | RAF1 | P04049 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | KIF5B | P33176 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982980 | 0.92 | EGFR (0.61) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7978607 | 0.87 | EGFR (0.60) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7980372 | 0.86 | EGFR (0.60) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7980482 | 0.85 | RET (0.58) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7979940 | 0.84 | EGFR (0.64) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7980461 | 0.84 | EGFR (0.61) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7980714 | 0.84 | EGFR (0.61) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7978778 | 0.83 | EGFR (0.60) | EGFRERBB2RETBRAFRAF1 | |
| SCHEMBL7966561 | 0.82 | RET (0.60) | EGFRERBB2RETBRAFKDR | |
| SCHEMBL7966337 | 0.82 | RET (0.60) | EGFRERBB2RETBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |