Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 10/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976817 | 0.87 | HPGD (0.62) | EGFRERBB2KDM4EALDH1A1HPGD | |
| SCHEMBL7980026 | 0.86 | EGFR (0.63) | EGFRERBB2RETKDR | |
| SCHEMBL7978595 | 0.84 | EGFR (0.62) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL7980461 | 0.84 | EGFR (0.61) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL7980714 | 0.82 | EGFR (0.61) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL7982980 | 0.82 | EGFR (0.61) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL7978778 | 0.81 | EGFR (0.60) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL7980372 | 0.81 | EGFR (0.60) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL7978607 | 0.80 | EGFR (0.60) | EGFRERBB2RETKDRBRAF | |
| SCHEMBL6662871 | 0.80 | KDR (0.77) | EGFRRETKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |