Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438507 | 0.78 | KMT2A (0.39) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL12531865 | 0.77 | PIK3CD (0.47) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL6648293 | 0.74 | KMT2A (0.35) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL23562819 | 0.71 | PIK3CD (0.41) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL441490 | 0.71 | GBA1 (0.38) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL5499434 | 0.70 | RAB9A (0.33) | KMT2AMEN1 | |
| SCHEMBL356238 | 0.70 | KMT2A (0.38) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL13600648 | 0.69 | MEN1 (0.36) | KMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL17162628 | 0.69 | KMT2A (0.52) | KMT2ACYP1A2CYP2C19MEN1NPC1 | |
| SCHEMBL178300 | 0.68 | KMT2A (0.44) | KMT2ACYP1A2CYP2C19MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6294532-B1 | TREATMENT OF A NUMBER OF DISEASE STATES INCLUDING CANCER AND RHEUMATOID ARTHRITIS. | ZENECA LIMITED (GB) | 2001-09-25 | — | — | US | disclosed |