Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.62 |
| ▸ | CDK4 | P11802 | 6/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10252038 | 0.83 | CDK2 (0.64) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL701210 | 0.82 | CDK2 (0.60) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL7975583 | 0.82 | CDK2 (0.60) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL7964828 | 0.80 | CDK2 (0.65) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL700855 | 0.77 | HDAC1 (0.64) | CDK2CDK4CCNE1PRKD3MAP4K4 | |
| SCHEMBL1684673 | 0.76 | CDK2 (0.74) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL7965083 | 0.76 | CDK2 (0.64) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL1684643 | 0.76 | CDK2 (0.86) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL699642 | 0.75 | CDK2 (0.61) | CDK2CDK4CCNE1KDM4EALDH1A1 | |
| SCHEMBL7964815 | 0.75 | CDK2 (0.63) | CDK2CDK4CCNE1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010009155-A2 | FUSED HETEROCYCLYC INHIBITOR COMPOUNDS | GILEAD COLORADO, INC. (US) | 2010-01-21 | — | — | WO | disclosed |