SCHEMBL7979381

SCHEMBL7979381

CCc1cc(OCC=C(Cl)Cl)cc(C)c1OCCCNC(=O)c1ccc(C(F)(F)F)cn1

nearest known ligand 0.44

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 17/20 0.44
SCN10A Q9Y5Y9 2/20 0.40
GCGR P47871 1/20 0.38
RHOC P08134 1/20 0.38
RHOA P61586 1/20 0.38
SCN7A Q01118 1/20 0.37
KCNH2 Q12809 1/20 0.37
SCN5A Q14524 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7965837 0.97 SCN9A (0.42) SCN9ASCN10AGCGRSCN7AKCNH2
SCHEMBL7977745 0.95 SCN9A (0.47) SCN9ASCN10ARHOCRHOASCN7A
SCHEMBL7979521 0.94 SCN9A (0.47) SCN9ASCN10AGCGRRHOCRHOA
SCHEMBL7979538 0.92 SCN9A (0.44) SCN9ASCN10ARHOCRHOASCN7A
SCHEMBL7979404 0.91 SCN9A (0.45) SCN9ASCN10AGCGRRHOCRHOA
SCHEMBL7977981 0.91 SCN9A (0.45) SCN9ASCN10AGCGRRHOCRHOA
SCHEMBL7979083 0.90 RHOC (0.44) RHOCRHOA
SCHEMBL7979635 0.88 SCN9A (0.42) SCN9ASCN10AGCGRRHOCRHOA
SCHEMBL7979322 0.87 PPARD (0.42) RHOCRHOA
SCHEMBL7079367 0.86 POLB (0.38) SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6214835-B1 CONTROLLING INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-04-10 US disclosed
EP-0824514-B1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL CO (JP) 2000-09-06 EP disclosed
US-6028100-A Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-02-22 US disclosed
US-5952386-A EXCELLENT INSECTICIDAL ACTIVITY FOR THE CONTROL OF NOXIOUS INSECTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-09-14 US disclosed
EP-0824514-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1998-02-25 EP disclosed
WO-1996033160-A1 DIHALOPROPENE COMPOUNDS, INSECTICIDES CONTAINING THEM AS ACTIVE INGREDIENTS, AND INTERMEDIATES FOR THEIR PRODUCTION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-10-24 WO disclosed