Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.65 |
| ▸ | PDE4A | P27815 | 9/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.65 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976353 | 0.90 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7982313 | 0.90 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7982349 | 0.87 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL13035036 | 0.84 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL157018 | 0.81 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| Sch-351591 SCHEMBL29378661 | 0.81 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7982331 | 0.81 | PDE4B (0.78) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7982474 | 0.79 | PDE4A (0.43) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL7979774 | 0.79 | PDE4A (0.56) | PDE4BPDE4APDE4CPDE4DPDE11A | |
| SCHEMBL8290205 | 0.77 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262070-B1 | E.G., 8-METHOXY-2-TRIFLUOROMETHYLQUINOLINE-5-CARBOXYLIC ACID(3,5-DICHLORO-1-OXYPYRIDIN-4-YL)AMIDE; TREATMENT OF CHRONIC OBSTRUCTIVE AIRWAYS DISEASE | DARWIN DISCOVERY LTD. (GB) | 2001-07-17 | — | — | US | claimed |