Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981043 | 0.87 | NPC1 (0.52) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29235235 | 0.85 | NPC1 (0.62) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL23942951 | 0.81 | NPC1 (0.46) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29235233 | 0.78 | NPC1 (0.53) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL31353051 | 0.77 | NPC1 (0.62) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29235298 | 0.75 | NPC1 (0.56) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL21875329 | 0.75 | MAP2K1 (0.44) | NPC1RAB9ASMN1; SMN2MAP2K1MAP2K2 | |
| SCHEMBL31353084 | 0.75 | NPC1 (0.49) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29235223 | 0.75 | NPC1 (0.49) | TP53NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL29235259 | 0.75 | NPC1 (0.49) | TP53NPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |