Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979756 | 0.87 | TP53 (0.51) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL29235235 | 0.86 | NPC1 (0.62) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL28124325 | 0.83 | GRM4 (0.53) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL23942951 | 0.82 | NPC1 (0.46) | NPC1RAB9ATP53SMN1; SMN2KMT2A | |
| SCHEMBL29235233 | 0.82 | NPC1 (0.53) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL31353051 | 0.78 | NPC1 (0.62) | NPC1RAB9ATP53SMN1; SMN2KMT2A | |
| SCHEMBL9986321 | 0.77 | GAA (0.50) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL29235298 | 0.76 | NPC1 (0.56) | NPC1RAB9ATP53SMN1; SMN2POLB | |
| SCHEMBL31353084 | 0.76 | NPC1 (0.49) | NPC1RAB9ATP53SMN1; SMN2MAPT | |
| SCHEMBL29235259 | 0.76 | NPC1 (0.49) | NPC1RAB9ATP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |