Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981079 | 0.76 | PTGS1 (0.67) | PTGS1PTGS2RAB9ALMNAALDH1A1 | |
| SCHEMBL6659912 | 0.73 | ALDH1A1 (0.70) | MAPTRAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL11688696 | 0.73 | ALDH1A1 (0.70) | MAPTRAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL7729899 | 0.72 | ALDH1A1 (0.58) | MAPTRAB9AL3MBTL1LMNAALDH1A1 | |
| SCHEMBL11685951 | 0.72 | MAPT (0.64) | MAPTL3MBTL1LMNAALDH1A1 | |
| SCHEMBL23783307 | 0.70 | ALDH1A1 (0.64) | MAPTRAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL28374567 | 0.69 | BCL9 (0.63) | MAPTRAB9AL3MBTL1ALDH1A1HTT | |
| SCHEMBL6141237 | 0.69 | ALDH1A1 (0.56) | MAPTRAB9AL3MBTL1ALDH1A1HTT | |
| SCHEMBL1555636 | 0.68 | ALDH1A1 (0.59) | MAPTRAB9AL3MBTL1ALDH1A1HTT | |
| SCHEMBL20579850 | 0.68 | CYP1A2 (0.75) | PTGS1PTGS2MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174877-B1 | EXCELLANT BACTERICIDES, ORAL ABSORBABILITY AND STABILITY; IMPROVE THE STABILITY TO RENAL DEHYDROPEPTIDASE I (DHP-I); 2-(2-(N-HETEROCYCLIC-ETHYLTHIO-) DERIVATIVES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-16 | — | — | US | disclosed |
| EP-0876370-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025325-A1 | CARBAPENEM COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |