Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980641 | 0.86 | LCK (0.67) | LCKKDM4EHPGDALDH1A1THRB | |
| SCHEMBL31500073 | 0.81 | LCK (0.61) | LCKKDM4EHPGDAPPALDH1A1 | |
| SCHEMBL7987006 | 0.80 | LCK (0.64) | LCKKDM4EHPGDALDH1A1 | |
| SCHEMBL7986755 | 0.76 | LCK (0.63) | LCKKDM4E | |
| SCHEMBL7983552 | 0.75 | LCK (0.67) | LCKKDM4EHPGDPPARGNR2E3 | |
| SCHEMBL7980569 | 0.75 | KDM4E (0.65) | LCKKDM4E | |
| SCHEMBL7969765 | 0.74 | LCK (0.73) | LCK | |
| SCHEMBL7980128 | 0.74 | EED (0.61) | LCK | |
| SCHEMBL7969596 | 0.74 | LCK (1.00) | LCK | |
| SCHEMBL7969734 | 0.74 | LCK (0.58) | LCKKDM4EHPGDPPARGNR2E3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |