Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.64 |
| ▸ | RAB9A | P51151 | 13/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.52 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5717831 | 0.88 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL5717616 | 0.88 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1812927 | 0.84 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL3517537 | 0.83 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL5206454 | 0.82 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL15291004 | 0.80 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL4037120 | 0.80 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL26525964 | 0.80 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1810603 | 0.78 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL7973730 | 0.77 | ALDH1A1 (0.60) | NPC1RAB9ASMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001007409-A1 | CARBAZOLE DERIVATIVES AND THEIR USE AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | ASTRAZENECA UK LIMITED (GB) | 2001-02-01 | — | — | WO | disclosed |