Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24184649 | 1.00 | KMT2A (0.48) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL9789720 | 0.98 | KMT2A (0.47) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL23480476 | 0.89 | KMT2A (0.49) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL9789645 | 0.88 | KMT2A (0.48) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL9789700 | 0.88 | KMT2A (0.48) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL9789713 | 0.88 | KMT2A (0.48) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL8552744 | 0.87 | KMT2A (0.39) | KMT2AALDH1A1MAPTKDM4EHSD17B10 | |
| SCHEMBL21899389 | 0.82 | EGLN1 (0.47) | KMT2AMAPTGAAPNMTMEN1 | |
| SCHEMBL7966594 | 0.82 | EGLN1 (0.47) | KMT2AMAPTGAAPNMTMEN1 | |
| Hydrochloric Acid SCHEMBL8384193 | 0.81 | EGLN1 (0.46) | KMT2AMAPTGAAPNMTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323215-B1 | TREAT AND PREVENT DISORDERS CHARACTERIZED BY NEURONAL DAMAGE SUCH AS PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, STROKE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, DIABETIC NEUROPATHY AND BELL'S PALSY. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-11-27 | — | — | US | disclosed |