Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 7/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29893558 | 1.00 | LCK (0.53) | LCKCSNK2A1KDM4EFGFR1BTK | |
| SCHEMBL31136680 | 0.90 | LCK (0.63) | LCKCSNK2A1KDM4EFGFR1BTK | |
| SCHEMBL7979815 | 0.84 | LCK (0.47) | LCKCSNK2A1FGFR1BTKCSNK2A2 | |
| SCHEMBL29893072 | 0.81 | KDM4E (0.50) | CSNK2A1KDM4EFGFR1CSNK2A2CSNK2B | |
| SCHEMBL29893318 | 0.80 | KDM4E (0.49) | LCKCSNK2A1KDM4EFGFR1CSNK2A2 | |
| SCHEMBL29893528 | 0.80 | KDM4E (0.52) | LCKCSNK2A1KDM4EFGFR1MAPT | |
| SCHEMBL31167541 | 0.79 | KDM4E (0.48) | CSNK2A1KDM4EFGFR1MAPT | |
| SCHEMBL31167537 | 0.79 | KDM4E (0.48) | CSNK2A1KDM4EFGFR1MAPT | |
| SCHEMBL29892855 | 0.79 | KDM4E (0.48) | CSNK2A1KDM4EFGFR1MAPTALDH1A1 | |
| SCHEMBL7987646 | 0.78 | LCK (0.86) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |