SCHEMBL7979993

SCHEMBL7979993

C=C(OC(C)(C)C)N1CCC(O)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.37
CHRM1 P11229 1/20 0.37
CHRM3 P20309 1/20 0.37
HPGD P15428 1/20 0.37
RECQL P46063 1/20 0.35
EPHX1 P07099 1/20 0.35
HRH3 Q9Y5N1 1/20 0.34
GPR119 Q8TDV5 3/20 0.33
HSP90AA1 P07900 1/20 0.33
HSP90AB1 P08238 1/20 0.33
HSD17B10 Q99714 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPT P10636 1/20 0.32
THRB P10828 1/20 0.32
PTPN2 P17706 1/20 0.32
PTPN1 P18031 1/20 0.32
PTPN6 P29350 1/20 0.32
USP2 O75604 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
ALDH1A1 P00352 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26151575 0.82 HRH3 (0.41) HPGDRECQLEPHX1HRH3GPR119
SCHEMBL26606124 0.79 HRH3 (0.38) HPGDRECQLEPHX1HRH3GPR119
SCHEMBL8313236 0.79 CHRM2 (0.35) CHRM2CHRM1CHRM3
SCHEMBL12204162 0.79 HPGD (0.41) HPGDEPHX1MAPTUSP2SMN1; SMN2
SCHEMBL13694454 0.77 RECQL (0.36) HPGDRECQLEPHX1HRH3GPR119
SCHEMBL19416588 0.77 HPGD (0.43) HPGDEPHX1MAPTUSP2SMN1; SMN2
SCHEMBL14611479 0.77 KDM4E (0.34) HPGDRECQLEPHX1GPR119KDM4E
SCHEMBL14142765 0.77 RECQL (0.37) HPGDRECQLEPHX1HRH3GPR119
SCHEMBL22545587 0.77 GNAI3 (0.39) GPR119
SCHEMBL27105788 0.77 HPGD (0.39) HPGDRECQLEPHX1HRH3GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024130342-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS UNIQUEST PTY LIMITED (AU) 2024-06-27 WO disclosed
WO-2008079988-A9 QUINAZOLINES FOR PDK1 INHIBITION NOVARTIS AG (CH) 2011-05-12 WO disclosed
WO-2009153313-A1 2 -ARYLAMINOQUINAZOLINES FOR TREATING PROLIFERATIVE DISEASES NOVARTIS AG (CH) 2009-12-23 WO disclosed
WO-2009138340-A1 INHIBITORS OF JNK F. HOFFMANN-LA ROCHE AG (CH) 2009-11-19 WO disclosed
WO-2008079988-A2 QUINAZOLINES FOR PDK1 INHIBITION NOVARTIS AG (CH) 2008-07-03 WO disclosed