Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 15/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.69 |
| ▸ | ENPP3 | O14638 | 4/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7457759 | 0.89 | ESR1 (0.85) | ESR1ESR2ENPP3ENPP1 | |
| Hydrochloric Acid SCHEMBL7457698 | 0.88 | ESR1 (0.84) | ESR1ESR2ENPP3ENPP1 | |
| Oxalic Acid SCHEMBL7456866 | 0.87 | ESR1 (0.80) | ESR1ESR2ENPP3ENPP1 | |
| Hydrochloric Acid SCHEMBL6552056 | 0.86 | ESR1 (0.78) | ESR1ESR2 | |
| SCHEMBL7450925 | 0.85 | ESR1 (0.89) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL7979806 | 0.84 | ENPP3 (0.74) | ESR1ESR2ENPP3ENPP1 | |
| Hydrochloric Acid SCHEMBL7460587 | 0.84 | ESR1 (0.88) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL7926834 | 0.84 | ESR1 (0.78) | ESR1ESR2 | |
| SCHEMBL7927574 | 0.84 | ESR1 (0.75) | ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL8467028 | 0.83 | ESR1 (0.86) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197790-B1 | OSTEOPOROSIS | ELI LILLY AND COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-6030986-A | POST-MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION; ESTROGEN INDUCED UTERINE CANCER; OSTEOPOROSIS; RESTENOSIS; CARDIOVASCULAR DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-29 | — | — | US | disclosed |
| US-5998441-A | ANTICHOLESTEROL AGENT; MIXTURE WITH ESTROGEN | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5986109-A | UROGENITAL DISORDERS, CARDIOVASCULAR DISORDERS AND ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 1999-11-16 | — | — | US | disclosed |
| US-5981765-A | FOR TREATMENT OF POST-MENOPAUSAL SYNDROME INCLUDING OSTEOPOROSIS, CARDIOVASCULAR EFFECTS SUCH AS HYPERLIPIDEMIA, AND ESTROGEN-DEPENDENT CANCER, PARTICULARLY BREAST AND UTERINE CANCER | ELI LILLY AND COMPANY (US) | 1999-11-09 | — | — | US | disclosed |
| US-5969142-A | OXIDIZING SULFUR ATOM OF SUBSTITUTED BENZOTHIOPHENE, REACTING PRODUCT WITH NUCLEOPHILIC GROUP, REDUCING PRODUCT TO DESIRED COMPOUND | ELI LILLY AND COMPANY (US) | 1999-10-19 | — | — | US | disclosed |