Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 9/20 | 0.54 |
| ▸ | PIM1 | P11309 | 6/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4320664 | 0.99 | PARP1 (0.56) | PARP1PIM1PIM2POLBTNKS | |
| SCHEMBL1559753 | 0.86 | PARP1 (0.46) | PARP1PIM1PIM2POLBTNKS | |
| SCHEMBL11647198 | 0.84 | TLR8 (0.47) | PARP1TNKSPARP15TNKS2KDM4E | |
| SCHEMBL1559705 | 0.83 | PARP1 (0.61) | PARP1PIM1PIM2TNKSPIM3 | |
| Hydrochloric Acid SCHEMBL1560782 | 0.82 | PARP1 (0.60) | PARP1PIM1PIM2TNKSPIM3 | |
| SCHEMBL11281218 | 0.80 | TLR8 (0.51) | PARP1TNKSMEN1KMT2APARP15 | |
| SCHEMBL11274767 | 0.76 | MAPK1 (0.48) | PARP1TNKSPARP15TNKS2KDM4E | |
| SCHEMBL1561076 | 0.76 | PARP1 (0.43) | PARP1PIM1PIM2POLBTNKS | |
| SCHEMBL1561103 | 0.73 | PARP1 (0.45) | PARP1POLBTNKSMEN1KMT2A | |
| SCHEMBL11288925 | 0.72 | MAPK1 (0.44) | PARP1TNKSPARP15TNKS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2896626-A1 | Thiazolyl- and oxazolyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2015-07-22 | — | — | EP | claimed |
| US-9265769-B2 | Thiazolyl- and oxazolyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2016-02-23 | — | — | US | disclosed |
| US-20150133443-A1 | Thiazolyl- And Oxazolyl-Isoquinolinones And Methods For Using Them | PELLICCIARI, ROBERTO (IT) | 2015-05-14 | — | — | US | disclosed |
| US-8906935-B2 | Thiazolyl- and oxazolyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2014-12-09 | — | — | US | disclosed |
| EP-2303895-B1 | THIAZOLYL- AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PELLICCIARI ROBERTO (IT) | 2014-09-24 | — | — | EP | disclosed |
| US-20130059843-A1 | Thiazolyl- and Oxazolyl-Isoquinolinones and Methods for Using Them | WYETH | 2013-03-07 | — | — | US | disclosed |
| US-8299090-B2 | Thiazolyl-and oxazolyl-isoquinolinones and methods for using them | Pellicciari, Roberto (IT) | 2012-10-30 | — | — | US | disclosed |
| US-20090318442-A1 | THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-24 | — | — | US | disclosed |
| WO-2009155402-A1 | THIAZOLYL- AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM | WYETH (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318442-A1 | THIAZOLYL-AND OXAZOLYL-ISOQUINOLINONES AND METHODS FOR USING THEM | PARP1, PARP2, PARP8 | PARP1 1/4885PIM1 1002/4885PIM2 900/4885 |
| US-20150133443-A1 | Thiazolyl- And Oxazolyl-Isoquinolinones And Methods For Using Them | PARP1, PARP2, PARP8 | PARP1 1/4885PIM1 981/4885PIM2 879/4885 |
| US-20130059843-A1 | Thiazolyl- and Oxazolyl-Isoquinolinones and Methods for Using Them | PARP1, PARP2, PARP8 | PARP1 1/4885PIM1 981/4885PIM2 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.