Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 14/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.41 |
| ▸ | TNKS | O95271 | 2/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11274767 | 0.95 | MAPK1 (0.48) | MAPK1PARP1TNKS2TNKSPARP15 | |
| SCHEMBL1561103 | 0.76 | PARP1 (0.45) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL11647198 | 0.76 | TLR8 (0.47) | PARP1TNKS2TNKSPARP15TLR8 | |
| SCHEMBL11274910 | 0.75 | PARP1 (0.49) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL11279989 | 0.75 | PARP1 (0.44) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL11281218 | 0.74 | TLR8 (0.51) | PARP1TNKS2TNKSPARP15TLR8 | |
| SCHEMBL11285870 | 0.74 | PARP1 (0.45) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL1560390 | 0.73 | PARP1 (0.41) | PARP1TNKS2TNKSPARP15KDM4E | |
| SCHEMBL7980353 | 0.72 | PARP1 (0.54) | PARP1TNKS2TNKSPARP15KDM4E | |
| Hydrochloric Acid SCHEMBL4320664 | 0.71 | PARP1 (0.56) | PARP1TNKS2TNKSPARP15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005745-B1 | PYRAZOLO (3,4-C) AND THIAZOLO (5,4-C) ISOQUINOLINES, METHODS FOR PREPARING THEM, THESE COMPOUNDS FOR USE AS ANTIINFLAMMATORY, CNS-DEPRESSANT AND ANTI-ANXIETY AGENTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | GRUPPO LEPETIT S.P.A. (IT) | 1982-07-14 | — | — | EP | disclosed |