Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326204 | 0.84 | NPC1 (0.47) | RAB9ASMN1; SMN2NPC1HPGDMAPT | |
| SCHEMBL7416384 | 0.84 | MAPT (0.51) | MAPTL3MBTL1ALDH1A1KMT2AKDM4E | |
| SCHEMBL7970370 | 0.82 | PDE4A (0.44) | SMN1; SMN2HDAC6HPGDMAPTMAPK1 | |
| SCHEMBL27566563 | 0.82 | HPGD (0.47) | SMN1; SMN2NPC1HPGDHSD17B10CYP2C9 | |
| SCHEMBL7296279 | 0.82 | TEAD1 (0.39) | MAPTMAPK1ALDH1A1KMT2AKDM4E | |
| SCHEMBL28743198 | 0.81 | NR1H4 (0.46) | HPGDMAPTCYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL7987870 | 0.81 | HPGD (0.40) | SMN1; SMN2HPGDMAPTALDH1A1KDM4E | |
| SCHEMBL7984229 | 0.81 | PDE4A (0.46) | SMN1; SMN2HPGDMAPTALDH1A1KMT2A | |
| SCHEMBL27517740 | 0.80 | HPGD (0.40) | RAB9ASMN1; SMN2NPC1HPGDMAPT | |
| SCHEMBL3176719 | 0.78 | TEAD1 (0.53) | RAB9ANPC1MAPTL3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |