Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288655 | 0.90 | SLC22A12 (0.43) | TEAD1TEAD4TEAD2SLC22A12ALDH1A1 | |
| SCHEMBL7416384 | 0.85 | MAPT (0.51) | KMT2AALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL3604069 | 0.85 | TEAD1 (0.43) | TEAD1TEAD4TEAD2SLC22A12ESR1 | |
| SCHEMBL3176719 | 0.85 | TEAD1 (0.53) | TEAD1TEAD4TEAD2SLC22A12KMT2A | |
| SCHEMBL7377745 | 0.84 | SLC22A12 (0.42) | TEAD1TEAD4TEAD2SLC22A12ESR1 | |
| SCHEMBL3604745 | 0.84 | TEAD1 (0.42) | TEAD1TEAD4TEAD2SLC22A12ESR1 | |
| SCHEMBL27701271 | 0.84 | TEAD1 (0.42) | TEAD1TEAD4TEAD2SLC22A12ESR1 | |
| SCHEMBL7970490 | 0.84 | TEAD1 (0.52) | TEAD1TEAD4TEAD2SLC22A12KMT2A | |
| SCHEMBL7294047 | 0.83 | CYP19A1 (0.36) | TEAD1TEAD4TEAD2SLC22A12ESR1 | |
| SCHEMBL7294038 | 0.83 | CYP19A1 (0.36) | TEAD1TEAD4TEAD2SLC22A12ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816357-B1 | Substituted indazole derivatives | PFIZER (US) | 2002-01-09 | — | — | EP | disclosed |
| US-5958953-A | Substituted indazole derivatives | PFIZER INC (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0816357-A1 | Substituted indazole derivatives | PFIZER INC. (US) | 1998-01-07 | — | — | EP | disclosed |