Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 5/20 | 0.67 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.63 |
| ▸ | IP6K3 | Q96PC2 | 4/20 | 0.63 |
| ▸ | IP6K2 | Q9UHH9 | 3/20 | 0.63 |
| ▸ | PARP1 | P09874 | 7/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8622180 | 0.93 | ACVR1 (0.73) | ACVR1IP6K1IP6K3PARP1PDPK1 | |
| SCHEMBL3739920 | 0.88 | IP6K1 (0.61) | ACVR1IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL3731351 | 0.87 | ACVR1 (0.60) | ACVR1IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL12476626 | 0.86 | PARP1 (0.62) | ACVR1IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL13820309 | 0.85 | PARP1 (0.78) | ACVR1IP6K1IP6K3PARP1CHEK1 | |
| SCHEMBL7980108 | 0.85 | QPCT (0.65) | ACVR1IP6K1IP6K3PARP1CHEK1 | |
| SCHEMBL30669818 | 0.85 | QPCT (0.65) | ACVR1IP6K1IP6K3PARP1CHEK1 | |
| SCHEMBL18712269 | 0.83 | ACVR1 (0.69) | ACVR1IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL24155902 | 0.82 | ACVR1 (0.61) | ACVR1IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL6869415 | 0.81 | ACVR1 (0.63) | ACVR1IP6K1PARP1PDPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |