Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170577 | 0.88 | PDK1 (0.41) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL1170399 | 0.88 | PDK1 (0.41) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL2434192 | 0.87 | PDK1 (0.42) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL12328094 | 0.86 | PDK1 (0.41) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL10262476 | 0.86 | JAK2 (0.42) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL12328090 | 0.86 | PDK1 (0.41) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL1170330 | 0.86 | JAK2 (0.42) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL1170610 | 0.86 | JAK2 (0.42) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL755045 | 0.86 | JAK2 (0.42) | PDK1PDK2PDK3PDK4HTR2C | |
| SCHEMBL21241492 | 0.77 | HTR2C (0.52) | PDK1PDK2PDK3PDK4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009136350-A1 | NOVEL CLASS OF SPIRO PIPERIDINES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | PFIZER INC. (US) | 2009-11-12 | — | — | WO | disclosed |