Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.66 |
| ▸ | FLT1 | P17948 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739014 | 0.90 | KDR (0.63) | KDRFLT1FLT4KDM4EPIK3CA | |
| SCHEMBL7983597 | 0.89 | KDR (0.65) | KDRFLT1FLT4PIK3CAPIK3CG | |
| SCHEMBL7979617 | 0.88 | KDR (0.55) | KDRFLT1FLT4KDM4EMAPT | |
| SCHEMBL7739078 | 0.88 | KDR (0.68) | KDRFLT1FLT4KDM4EMAPT | |
| SCHEMBL7739065 | 0.85 | KDR (0.50) | KDRFLT1FLT4TDP1POLB | |
| SCHEMBL7983232 | 0.85 | KDR (0.57) | KDRFLT1FLT4KDM4EMAPT | |
| SCHEMBL7980821 | 0.83 | KDR (0.54) | KDRFLT1FLT4TDP1POLB | |
| SCHEMBL7744641 | 0.82 | KDR (0.55) | KDRFLT1FLT4KDM4EMAPT | |
| SCHEMBL7739087 | 0.82 | KDR (0.69) | KDRFLT1FLT4TDP1POLB | |
| SCHEMBL7744663 | 0.80 | KDR (0.76) | KDRFLT1FLT4POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |