Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739014 | 0.94 | KDR (0.63) | KDRFLT1FLT4PIK3CAPIK3CG | |
| SCHEMBL7983597 | 0.88 | KDR (0.65) | KDRFLT1FLT4PIK3CAPIK3CG | |
| SCHEMBL7980820 | 0.88 | KDR (0.66) | KDRFLT1FLT4MAPTMEN1 | |
| SCHEMBL7979621 | 0.86 | KDR (0.50) | KDRFLT1FLT4MAPTMEN1 | |
| SCHEMBL7739065 | 0.85 | KDR (0.50) | KDRFLT1FLT4MAPTMEN1 | |
| SCHEMBL7983232 | 0.85 | KDR (0.57) | KDRFLT1FLT4MAPTPIK3CA | |
| SCHEMBL7744663 | 0.84 | KDR (0.76) | KDRFLT1FLT4MAPTPIK3CG | |
| SCHEMBL7744167 | 0.83 | HDAC1 (0.53) | KDRFLT1FLT4GAANPC1 | |
| SCHEMBL7744651 | 0.80 | HPGD (0.51) | KDRFLT1FLT4RAB9ACYP1A2 | |
| SCHEMBL7982616 | 0.80 | KDR (0.56) | KDRFLT1FLT4PIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |