Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 14/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980974 | 0.91 | ADRB3 (0.39) | ADRB3ADRA1ALMNATP53MAPT | |
| SCHEMBL7980808 | 0.91 | ADRB3 (0.39) | DRD2ADRB3ADRA1ALMNATP53 | |
| SCHEMBL7980812 | 0.91 | ADRB3 (0.39) | DRD2ADRB3ADRA1ALMNATP53 | |
| SCHEMBL7980970 | 0.91 | ADRB3 (0.39) | ADRB3ADRA1ALMNATP53MAPT | |
| SCHEMBL7979197 | 0.88 | ADRB3 (0.52) | DRD2DRD3ADRB3ADRA1ADRD4 | |
| SCHEMBL5193489 | 0.87 | DRD2 (0.44) | DRD2DRD3ADRB3ADRA1ADRD4 | |
| SCHEMBL5193784 | 0.87 | DRD2 (0.44) | DRD2DRD3ADRB3ADRA1ADRD4 | |
| SCHEMBL7123003 | 0.86 | DRD2 (0.47) | DRD2DRD3ADRB3ADRA1ADRD4 | |
| SCHEMBL7108285 | 0.86 | DRD2 (0.47) | DRD2DRD3ADRB3ADRA1ADRD4 | |
| SCHEMBL7108283 | 0.86 | DRD2 (0.47) | DRD2DRD3ADRB3ADRA1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |