Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | CLPP | Q16740 | 5/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981495 | 0.90 | MEN1 (0.46) | GAAMEN1KMT2ADRD2DRD4 | |
| SCHEMBL7970219 | 0.86 | MEN1 (0.46) | GAAMEN1KMT2ADRD2DRD4 | |
| SCHEMBL7983703 | 0.85 | BRS3 (0.45) | GAADRD2DRD3CLPPSIGMAR1 | |
| SCHEMBL7970103 | 0.85 | MEN1 (0.50) | GAAMEN1KMT2AATMDRD2 | |
| SCHEMBL7983931 | 0.81 | DRD4 (0.43) | DRD2DRD4DRD3CLPPMAPK1 | |
| SCHEMBL7984338 | 0.80 | SIGMAR1 (0.45) | GAAMEN1KMT2ADRD2DRD4 | |
| SCHEMBL7981751 | 0.78 | SIGMAR1 (0.51) | SIGMAR1 | |
| SCHEMBL6790350 | 0.77 | GRIA1 (0.51) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL7983949 | 0.77 | DRD4 (0.43) | DRD2DRD4DRD3CLPPMAPK1 | |
| SCHEMBL6789476 | 0.75 | MAPT (0.42) | GAAMAPK1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197771-B1 | NERVOUS SYSTEM DISORDERS; ANTIISCHEMIC AGENTS; ALZHEIMER'SDISEASE; PARKINSON'S DISEASE; HUNTINGTON'S DISEASE | WARNER-LAMBERT COMPANY | 2001-03-06 | — | — | US | claimed |
| WO-1996028445-A1 | NOVEL GLUTAMATE (AMPA/KAINATE) RECEPTOR ANTAGONISTS: N-SUBSTITUTED FUSED AZACYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-09-19 | — | — | WO | claimed |
| US-6197771-B1 | NERVOUS SYSTEM DISORDERS; ANTIISCHEMIC AGENTS; ALZHEIMER'SDISEASE; PARKINSON'S DISEASE; HUNTINGTON'S DISEASE | WARNER-LAMBERT COMPANY | 2001-03-06 | — | — | US | disclosed |
| US-6057313-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY (US) | 2000-05-02 | — | — | US | disclosed |
| WO-1996028445-A1 | NOVEL GLUTAMATE (AMPA/KAINATE) RECEPTOR ANTAGONISTS: N-SUBSTITUTED FUSED AZACYCLOALKYLQUINOXALINEDIONES | WARNER-LAMBERT COMPANY (US) | 1996-09-19 | — | — | WO | disclosed |