Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 13/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981042 | 1.00 | ADRB3 (0.38) | ADRB3BACE1SLC22A12PTGS1PTGS2 | |
| SCHEMBL7105482 | 0.86 | ADRB3 (0.38) | ADRB3BACE1PTGS1PTGS2TRPV1 | |
| SCHEMBL2240456 | 0.86 | ADRB3 (0.38) | ADRB3BACE1PTGS1PTGS2TRPV1 | |
| SCHEMBL7105760 | 0.86 | ADRB3 (0.38) | ADRB3TRPV1 | |
| SCHEMBL176915 | 0.86 | ADRB3 (0.38) | ADRB3BACE1PTGS1PTGS2TRPV1 | |
| SCHEMBL2243705 | 0.86 | ADRB3 (0.38) | ADRB3TRPV1 | |
| SCHEMBL177028 | 0.86 | ADRB3 (0.38) | ADRB3TRPV1 | |
| SCHEMBL5195520 | 0.79 | KIF11 (0.41) | ADRB3PTGS1 | |
| SCHEMBL5195514 | 0.79 | KIF11 (0.41) | ADRB3PTGS1 | |
| SCHEMBL6479480 | 0.79 | CYP19A1 (0.44) | ADRB3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6172099-B1 | CARBAZOLE, DIBENZOFURAN, OR DIBENZOTHIOPHENE DERIVATIVES; DIETETICS, ANTIDIABETIC AGENTS; ANTILIPEMICS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0997458-A1 | NOVEL TRICYCLIC COMPOUNDS HAVING SATURATED RINGS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 2000-05-03 | — | — | EP | disclosed |