Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 16/20 | 0.42 |
| ▸ | LYN | P07948 | 3/20 | 0.34 |
| ▸ | BTK | Q06187 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981461 | 0.91 | LCK (0.46) | LCK | |
| SCHEMBL7981177 | 0.88 | LCK (0.46) | LCKLYNBTK | |
| SCHEMBL7983009 | 0.85 | LCK (0.53) | LCKLYNBTK | |
| SCHEMBL7979983 | 0.80 | LCK (0.45) | LCKLYNBTK | |
| SCHEMBL7969753 | 0.78 | LCK (0.51) | LCKLYNBTK | |
| SCHEMBL7969939 | 0.75 | LCK (0.44) | LCKLYNBTK | |
| SCHEMBL7983392 | 0.74 | LCK (0.52) | LCKLYNBTK | |
| SCHEMBL7986958 | 0.72 | LCK (0.44) | LCK | |
| SCHEMBL7987020 | 0.72 | LCK (0.44) | LCK | |
| SCHEMBL7983073 | 0.69 | LCK (0.57) | LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | disclosed |