Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978483 | 1.00 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTSERPINE1ALDH1A1LMNA | |
| SCHEMBL1653895 | 0.88 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTSERPINE1ALDH1A1LMNA | |
| SCHEMBL13554691 | 0.84 | MAPT (0.71) | SMN1; SMN2MAPTSERPINE1ALDH1A1KMT2A | |
| SCHEMBL38658481 | 0.84 | GAA (0.50) | SMN1; SMN2MAPTSERPINE1ALDH1A1LMNA | |
| SCHEMBL2064392 | 0.82 | TDP1 (0.63) | SMN1; SMN2MAPTSERPINE1ALDH1A1KMT2A | |
| SCHEMBL27692447 | 0.82 | TDP1 (0.63) | SMN1; SMN2MAPTSERPINE1ALDH1A1KMT2A | |
| SCHEMBL27242800 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL27242721 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL11453714 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL11055247 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2MAPTSERPINE1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225306-B1 | PYRROLO(1,2A)QUINOXALINES | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 2001-05-01 | — | — | US | disclosed |
| EP-0987266-A1 | BIPHENYL DERIVATIVES AND MEDICINAL COMPOSITIONS | Wakamoto Pharmaceutical Co., Ltd. (JP) | 2000-03-22 | — | — | EP | disclosed |