SCHEMBL7981655

SCHEMBL7981655

COc1cc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4c3nc(OC)n4C)c2Cl)ccc1NC(C)=O

nearest known ligand 0.82

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7981653 1.00 BDKRB2 (0.82) BDKRB2
SCHEMBL7965243 0.94 BDKRB2 (0.81) BDKRB2
SCHEMBL7965240 0.94 BDKRB2 (0.81) BDKRB2
SCHEMBL7978830 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL7978832 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL7977454 0.89 BDKRB2 (0.83) BDKRB2
SCHEMBL7977452 0.89 BDKRB2 (0.83) BDKRB2
SCHEMBL7978806 0.88 BDKRB2 (0.81) BDKRB2
SCHEMBL7978802 0.88 BDKRB2 (0.81) BDKRB2
SCHEMBL7981714 0.87 BDKRB2 (0.84) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6194396-B1 ANTIALLERGENS; ANTIINFLAMMATION AGENTS; AUTOIMMUNE DISEASE; ANTISHOCK AGENTS; ANALGESICS; E.G., A 4 OR 7-PHENYLALKYLENE-OXYBENZIMIDAZOLE UNSUBSTITUTED OR SUBSTITUTED IN THE 1,2,3-POSITION WITH AN OXY, AMINO AND/OR THIO GROUP FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-02-27 US disclosed
US-6083961-A FOR PREVENTION AND/OR TREATMENT OF BRADYKININ OR ITS ANALOGUES MEDIATED DISEASES SUCH AS ALLERGY, INFLAMMATION, AUTOIMMUNE DISEASE, SHOCK, PAIN FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-07-04 US disclosed
EP-0774462-A1 HETEROCYCLIC COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-05-21 EP disclosed