SCHEMBL7981732

SCHEMBL7981732

Cn1c(-c2ccc(N)cc2F)nnc1C(C)(C)Oc1ccc(Cl)cc1F

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 5/20 0.47
HSD11B2 P80365 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12677424 0.93 HSD11B1 (0.47) HSD11B1HSD11B2
SCHEMBL7993129 0.89 HSD11B1 (0.49) HSD11B1
SCHEMBL12677300 0.89 MAPK14 (0.36) HSD11B1
SCHEMBL12677412 0.88 HSD11B1 (0.38) HSD11B1
SCHEMBL7992173 0.88 HSD11B1 (0.40) HSD11B1
SCHEMBL7979711 0.86 HSD11B1 (0.36) HSD11B1HSD11B2
SCHEMBL7987584 0.85 HSD11B1 (0.43) HSD11B1
SCHEMBL12671322 0.84 HSD11B1 (0.45) HSD11B1
SCHEMBL7968569 0.84 HSD11B1 (0.46) HSD11B1HSD11B2
SCHEMBL7982083 0.83 HSD11B1 (0.51) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010001946-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF アステラス製薬株式会社 (JP) 2010-01-07 WO disclosed