Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974196 | 0.81 | CHEK2 (0.55) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL7973859 | 0.75 | NPC1 (0.53) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL20445328 | 0.70 | NPC1 (1.00) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL7961557 | 0.69 | PTGDR2 (0.49) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL20982659 | 0.68 | NPC1 (0.85) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL4186413 | 0.68 | NPC1 (0.94) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL3125413 | 0.66 | NPC1 (0.75) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL14930221 | 0.66 | NPC1 (0.65) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL13329870 | 0.64 | NPC1 (0.66) | NPC1RAB9ATP53HPGDALDH1A1 | |
| SCHEMBL11903492 | 0.64 | NPC1 (0.66) | NPC1RAB9ATP53HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |