Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982509 | 0.81 | KDR (0.52) | KDRFLT1FLT4KDM4EMEN1 | |
| SCHEMBL7744180 | 0.74 | KDR (0.72) | KDRFLT1FLT4HDAC3HDAC1 | |
| SCHEMBL7744659 | 0.71 | KDR (0.50) | KDRFLT1FLT4HDAC1ADORA1 | |
| SCHEMBL7746658 | 0.71 | KDR (0.55) | KDRFLT1FLT4ADORA1KDM4E | |
| SCHEMBL7739022 | 0.71 | KDR (0.54) | KDRFLT1FLT4HDAC1ADORA1 | |
| SCHEMBL7739024 | 0.69 | KDR (0.50) | KDRFLT1FLT4ADORA1FABP4 | |
| SCHEMBL7744660 | 0.68 | KDR (0.44) | KDRFLT1FLT4ADORA1FABP4 | |
| SCHEMBL7744192 | 0.68 | KDR (0.51) | KDRFLT1FLT4ADORA1KDM4E | |
| SCHEMBL7744041 | 0.67 | HPGD (0.46) | KDRFLT1FLT4HDAC1ADORA1 | |
| SCHEMBL7744162 | 0.67 | KDR (0.45) | KDRFLT1FLT4HDAC1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |