Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040936 | 0.84 | KDR (0.73) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148552 | 0.82 | KDR (0.49) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL7982226 | 0.81 | KDR (0.49) | KDRFLT1FLT4MAPTMEN1 | |
| SCHEMBL14148538 | 0.81 | TP53 (0.57) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148572 | 0.81 | TP53 (0.47) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148571 | 0.79 | KDR (0.62) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148536 | 0.78 | KDR (0.49) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148568 | 0.75 | TP53 (0.54) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148527 | 0.75 | TP53 (0.46) | KDRFLT1FLT4TP53MAPT | |
| SCHEMBL14148561 | 0.75 | TP53 (0.50) | KDRFLT1FLT4TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |