Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 8/20 | 0.76 |
| ▸ | F9 | P00740 | 4/20 | 0.76 |
| ▸ | F11 | P03951 | 3/20 | 0.76 |
| ▸ | F7 | P08709 | 3/20 | 0.76 |
| ▸ | PLAU | P00749 | 5/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.49 |
| ▸ | F2 | P00734 | 5/20 | 0.47 |
| ▸ | PLG | P00747 | 4/20 | 0.47 |
| ▸ | PLAT | P00750 | 4/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973776 | 0.86 | F10 (1.00) | F10F9F11F7PLAU | |
| SCHEMBL16258936 | 0.85 | F10 (0.76) | F10F9F11F7PLAU | |
| SCHEMBL7972717 | 0.80 | F9 (0.77) | F10F9F11F7CHEK2 | |
| SCHEMBL7978435 | 0.78 | F10 (0.83) | F10F9F11F7PLAU | |
| SCHEMBL7978212 | 0.76 | F9 (0.65) | F10F9F11F7CHEK2 | |
| SCHEMBL7974859 | 0.76 | F9 (0.68) | F10F9F11F7PLAU | |
| SCHEMBL7959410 | 0.75 | F10 (0.79) | F10F9F11F7PLAU | |
| SCHEMBL10139860 | 0.75 | F9 (0.69) | F10F9F11F7CHEK2 | |
| SCHEMBL7972721 | 0.74 | CHEK2 (0.67) | F10F9F11F7CHEK2 | |
| SCHEMBL10140089 | 0.74 | PLAU (0.48) | F10F9F11F7PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2805939-B1 | Heterocyclic compounds as factor IXA inhibitors. | MERCK SHARP & DOHME (US) | 2018-06-27 | — | — | EP | disclosed |
| EP-2805939-A1 | Heterocyclic compounds as factor IXA inhibitors. | Merck Sharp & Dohme Corp. (US) | 2014-11-26 | — | — | EP | disclosed |
| WO-2009143039-A2 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | SCHERING CORPORATION (US) | 2009-11-26 | — | — | WO | disclosed |