Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.46 |
| ▸ | F10 | P00742 | 6/20 | 0.44 |
| ▸ | F2 | P00734 | 4/20 | 0.44 |
| ▸ | F9 | P00740 | 3/20 | 0.44 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.44 |
| ▸ | F7 | P08709 | 3/20 | 0.43 |
| ▸ | F11 | P03951 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HPN | P05981 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10140070 | 0.87 | PLAU (0.49) | PLAUPRSS1CHEK2F10F2 | |
| SCHEMBL10140086 | 0.86 | PLAU (0.67) | PLAUPRSS1CHEK2F10F2 | |
| SCHEMBL10140839 | 0.77 | CHEK2 (0.44) | PLAUPRSS1CHEK2F10F2 | |
| SCHEMBL10140363 | 0.77 | CHEK2 (0.41) | PLAUPRSS1CHEK2F10F2 | |
| SCHEMBL24312914 | 0.75 | CHEK2 (0.58) | PLAUPRSS1CHEK2HDAC3HDAC1 | |
| SCHEMBL7982582 | 0.74 | F10 (0.76) | PLAUPRSS1CHEK2F10F2 | |
| SCHEMBL24313037 | 0.71 | CHEK2 (0.61) | PLAUPRSS1CHEK2PLGHDAC3 | |
| SCHEMBL7974196 | 0.68 | CHEK2 (0.55) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL11327140 | 0.65 | RHEB (0.46) | PLAUPRSS1CHEK2HDAC6 | |
| SCHEMBL20982708 | 0.65 | HDAC6 (0.63) | PLAUPRSS1PLGHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148363-B2 | Heterocyclic compounds as factor IXA inhibitors | SCHERING CORPORATION (US) | 2012-04-03 | — | — | US | disclosed |
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | MERCK SHARP & DOHME LLC | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065682-A1 | HETEROCYCLIC COMPOUNDS AS FACTOR IXA INHIBITORS | F9, F12, F8 | PLAU 67/4885PRSS1 309/4885CHEK2 4794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.