Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 4/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978317 | 0.90 | POLB (0.36) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7834891 | 0.90 | POLB (0.36) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7978320 | 0.90 | POLB (0.36) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7977010 | 0.90 | POLB (0.36) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7980385 | 0.87 | POLB (0.35) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7979912 | 0.87 | TDP1 (0.35) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7979910 | 0.87 | TDP1 (0.35) | POLBHPGDPTAFRCHRNA7HTT | |
| SCHEMBL7832670 | 0.81 | POLB (0.37) | POLBHPGDPTAFRHTTSMN1; SMN2 | |
| SCHEMBL7822038 | 0.81 | POLB (0.37) | POLBHPGDPTAFRHTTSMN1; SMN2 | |
| SCHEMBL7983238 | 0.79 | POLB (0.41) | POLBHPGDPTAFRCHRNA7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | disclosed |