Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 10/20 | 0.52 |
| ▸ | PFKFB4 | Q16877 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793780 | 0.86 | PFKFB4 (0.57) | PFKFB3PFKFB4MAPTTP53CASP6 | |
| SCHEMBL796409 | 0.86 | PFKFB3 (0.66) | PFKFB3PFKFB4CASP6 | |
| SCHEMBL794116 | 0.85 | PFKFB4 (0.56) | PFKFB3PFKFB4MAPTTP53CASP6 | |
| SCHEMBL794024 | 0.85 | PFKFB3 (0.73) | PFKFB3PFKFB4MAPTTP53 | |
| SCHEMBL793709 | 0.83 | PFKFB4 (0.70) | PFKFB3PFKFB4MAPTTP53CASP6 | |
| SCHEMBL794063 | 0.83 | PFKFB4 (0.59) | PFKFB3PFKFB4MAPT | |
| SCHEMBL794137 | 0.83 | PFKFB3 (0.57) | PFKFB3PFKFB4CASP6 | |
| SCHEMBL795010 | 0.82 | PFKFB3 (0.68) | PFKFB3PFKFB4MAPTTP53LMNA | |
| SCHEMBL794168 | 0.82 | PFKFB3 (0.60) | PFKFB3PFKFB4MAPTTP53LMNA | |
| SCHEMBL794521 | 0.82 | PFKFB4 (0.57) | PFKFB3PFKFB4MAPTTP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616450-A2 | SULFONAMIDE COMPOUNDS | Kancera AB (SE) | 2013-07-24 | — | — | EP | claimed |
| WO-2012035171-A2 | NEW COMPOUNDS | KANCERA AB (SE) | 2012-03-22 | — | — | WO | claimed |
| WO-2020080979-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO DISCOVERY LIMITED LIABILITY COMPANY (RU) | 2020-04-23 | — | — | WO | disclosed |